Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1. Consequently, loss of RIPK1 in keratinocytes induces ZBP1-dependent necroptosis and s...

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發表在:J Exp Med
Main Authors: Devos, Michael, Tanghe, Giel, Gilbert, Barbara, Dierick, Evelien, Verheirstraeten, Maud, Nemegeer, Josephine, de Reuver, Richard, Lefebvre, Sylvie, De Munck, Jolien, Rehwinkel, Jan, Vandenabeele, Peter, Declercq, Wim, Maelfait, Jonathan
格式: Artigo
語言:Inglês
出版: Rockefeller University Press 2020
主題:
Brief Definitive Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336309/
https://ncbi.nlm.nih.gov/pubmed/32315377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191913
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