RIPK1 and RIPK3 kinases promote cell death-independent inflammation by Toll-like receptor 4

Macrophages are a crucial component of the innate immune system in sensing pathogens and promoting local and systemic inflammation. RIPK1 and RIPK3 are homologous kinases, previously linked to activation of necroptotic death. In this study we have described roles for these kinases as master regulato...

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Vydáno v:Immunity
Hlavní autoři: Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael, Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956514/
https://ncbi.nlm.nih.gov/pubmed/27396959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.007
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