Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia

BACKGROUND: Adoptive immunotherapy using T cells expressing chimeric antigen receptors (CARs) targeting CD19 has produced remarkable clinical outcomes. However, much of the mechanisms of action, such as the development of memory responses and sources of immune cytokines, remain elusive largely due t...

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Dades bibliogràfiques
Publicat a:EBioMedicine
Autors principals: Jin, Chun-Hui, Xia, Jinxing, Rafiq, Sarwish, Huang, Xin, Hu, Zheng, Zhou, Xianzheng, Brentjens, Renier J., Yang, Yong-Guang
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
Matèries:
Research paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354733/
https://ncbi.nlm.nih.gov/pubmed/30579863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.013
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