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CD28z CARs and Armored CARs

CD19-targeted chimeric antigen receptor (CAR) T cells are currently being tested in the clinic with very promising outcomes. However, limitations to CAR T cell therapy exist. These include lack of efficacy against some tumors, specific targeting of tumor cells without affecting normal tissue and ret...

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Podrobná bibliografie
Vydáno v:Cancer J
Hlavní autoři: Pegram, Hollie J., Park, Jae H., Brentjens, Renier J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687893/
https://ncbi.nlm.nih.gov/pubmed/24667958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PPO.0000000000000034
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