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Armored CAR T-cells: utilizing cytokines and pro-inflammatory ligands to enhance CAR T-cell anti-tumour efficacy

Chimaeric antigen receptor (CAR) T-cells are T-cells that have been genetically modified to express an artificial construct consisting of a synthetic T-cell receptor (TCR) targeted to a predetermined antigen expressed on a tumour. Coupling the T-cell receptor to a CD3ζ signalling domain paved the wa...

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Detalhes bibliográficos
Publicado no:Biochem Soc Trans
Main Authors: Yeku, Oladapo O., Brentjens, Renier J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529098/
https://ncbi.nlm.nih.gov/pubmed/27068948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20150291
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