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Cytokine IL-36γ Improves CAR T Cell Functionality and Induces Endogenous Anti-Tumor Response

Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in B cell malignancies. However, many patients suffer from limited response and tumor relapse due to lack of persisting CAR T cells and immune escape. These clinical challenges have compromised the long-term efficacy of CA...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Li, Xinghuo, Daniyan, Anthony F., Lopez, Andrea V., Purdon, Terence J., Brentjens, Renier J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680719/
https://ncbi.nlm.nih.gov/pubmed/32447345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0874-1
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