CD40 Ligand-Modified Chimeric Antigen Receptor (CAR) T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response

Chimeric antigen receptor (CAR) T cells provide great efficacy in B cell malignancies. However, improved CAR T cell therapies are still needed. Here, we engineered tumor-targeted CAR T cells to constitutively express the immune-stimulatory molecule CD40 ligand (CD40L) and explored efficacy in differ...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Kuhn, Nicholas F., Purdon, Terence J., van Leeuwen, Dayenne G., Lopez, Andrea V., Curran, Kevin J., Daniyan, Anthony F., Brentjens, Renier J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428219/
https://ncbi.nlm.nih.gov/pubmed/30889381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.02.006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados