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At the Bench: Chimeric antigen receptor (CAR) T cell therapy for the treatment of B cell malignancies

The chimeric antigen receptor (CAR) represents the epitome of cellular engineering and is one of the best examples of rational biologic design of a synthetic molecule. The CAR is a single polypeptide with modular domains, consisting of an antibody‐derived targeting moiety, fused in line with T cell‐...

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Pubblicato in:J Leukoc Biol
Autori principali: Daniyan, Anthony F. O., Brentjens, Renier J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608016/
https://ncbi.nlm.nih.gov/pubmed/27789538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5BT1215-556RR
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