Enhancing Antitumor Efficacy of Chimeric Antigen Receptor T Cells Through Constitutive CD40L Expression

Adoptive cell therapy with genetically modified T cells expressing a chimeric antigen receptor (CAR) is a promising therapy for patients with B-cell acute lymphoblastic leukemia. However, CAR-modified T cells (CAR T cells) have mostly failed in patients with solid tumors or low-grade B-cell malignan...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Curran, Kevin J, Seinstra, Beatrijs A, Nikhamin, Yan, Yeh, Raymond, Usachenko, Yelena, van Leeuwen, Dayenne G, Purdon, Terence, Pegram, Hollie J, Brentjens, Renier J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395796/
https://ncbi.nlm.nih.gov/pubmed/25582824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.4
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