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Chimeric Antigen Receptors for T cell Immunotherapy: Current Understanding and Future Direction
BACKGROUND: The genetic engineering of T cells through the introduction of a chimeric antigen receptor (CAR) allows for generation of tumor targeted T cells. Once expressed by T cells, CARs combine antigen-specificity with T cell activation in a single fusion molecule. Most CARs are comprised of an...
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| Udgivet i: | J Gene Med |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697438/ https://ncbi.nlm.nih.gov/pubmed/22262649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.2604 |
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