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Chimeric Antigen Receptors for T cell Immunotherapy: Current Understanding and Future Direction

BACKGROUND: The genetic engineering of T cells through the introduction of a chimeric antigen receptor (CAR) allows for generation of tumor targeted T cells. Once expressed by T cells, CARs combine antigen-specificity with T cell activation in a single fusion molecule. Most CARs are comprised of an...

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Bibliografische gegevens
Gepubliceerd in:J Gene Med
Hoofdauteurs: Curran, Kevin J., Pegram, Hollie J., Brentjens, Renier J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697438/
https://ncbi.nlm.nih.gov/pubmed/22262649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.2604
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