Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia

BACKGROUND: Adoptive immunotherapy using T cells expressing chimeric antigen receptors (CARs) targeting CD19 has produced remarkable clinical outcomes. However, much of the mechanisms of action, such as the development of memory responses and sources of immune cytokines, remain elusive largely due t...

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Podrobná bibliografie
Vydáno v:EBioMedicine
Hlavní autoři: Jin, Chun-Hui, Xia, Jinxing, Rafiq, Sarwish, Huang, Xin, Hu, Zheng, Zhou, Xianzheng, Brentjens, Renier J., Yang, Yong-Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
Témata:
Research paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354733/
https://ncbi.nlm.nih.gov/pubmed/30579863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.013
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