Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia

BACKGROUND: Adoptive immunotherapy using T cells expressing chimeric antigen receptors (CARs) targeting CD19 has produced remarkable clinical outcomes. However, much of the mechanisms of action, such as the development of memory responses and sources of immune cytokines, remain elusive largely due t...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Jin, Chun-Hui, Xia, Jinxing, Rafiq, Sarwish, Huang, Xin, Hu, Zheng, Zhou, Xianzheng, Brentjens, Renier J., Yang, Yong-Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354733/
https://ncbi.nlm.nih.gov/pubmed/30579863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.013
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