Evaluation of a PET Radioligand to Image O-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse

Accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important role in the progression of Alzheimer disease. Animal studies suggest that one strategy for treating Alzheimer disease and related tauopathies may be inhibition of O-GlcNAcase (OGA), which may subsequently d...

詳細記述

保存先:
書誌詳細
出版年:J Nucl Med
主要な著者: Paul, Soumen, Haskali, Mohammad B., Liow, Jeih-San, Zoghbi, Sami S., Barth, Vanessa N., Kolodrubetz, Marcy Comly, Bond, Michelle R., Morse, Cheryl L., Gladding, Robert L., Frankland, Michael P., Kant, Nancy, Slieker, Lawrence, Shcherbinin, Sergey, Nuthall, Hugh N., Zanotti-Fregonara, Paolo, Hanover, John A., Jesudason, Cynthia, Pike, Victor W., Innis, Robert B.
フォーマット: Artigo
言語:Inglês
出版事項: Society of Nuclear Medicine 2019
主題:
Neurology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354227/
https://ncbi.nlm.nih.gov/pubmed/30213846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.213231
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