Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2

p53 is frequently mutated in human cancers. Its levels are tightly regulated by the E3 ubiquitin ligase MDM2. The complex between MDM2 and p53 is largely formed by the interaction between the N-terminal domain of MDM2 and the N-terminal transactivation (TA) domain of p53 (residues 15–29). We investi...

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Vydáno v:Sci Rep
Hlavní autoři: Yadahalli, Shilpa, Neira, José L., Johnson, Christopher M., Tan, Yaw Sing, Rowling, Pamela J. E., Chattopadhyay, Anasuya, Verma, Chandra S., Itzhaki, Laura S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345774/
https://ncbi.nlm.nih.gov/pubmed/30679555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36589-5
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