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Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. Complementing earlier observations, the current study suggests that the p53 peptides largely foll...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5688104/ https://ncbi.nlm.nih.gov/pubmed/29142290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15930-4 |
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