Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53

Murine double minute 4 protein (MDMX) is crucial for the regulation of the tumor suppressor protein p53. Phosphorylation of the N-terminal domain of MDMX is thought to affect its binding with the transactivation domain of p53, thus playing a role in p53 regulation. In this study, the effects of MDMX...

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Pubblicato in:Oncotarget
Autori principali: Chan, Jane Vin, Ping Koh, Dawn Xin, Liu, Yun, Joseph, Thomas L., Lane, David P., Verma, Chandra S., Tan, Yaw Sing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762554/
https://ncbi.nlm.nih.gov/pubmed/29348869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22829
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