Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions

The 78-kDa glucose-regulated protein (GRP78) is an ER molecular chaperone that aids in protein folding and secretion. However, pathological conditions that cause ER stress can promote the relocalization of GRP78 to the cell surface (csGRP78), where it acts as a signaling receptor to promote cancer p...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Crane, Elizabeth D., Al-Hashimi, Ali A., Chen, Jack, Lynn, Edward G., Won, Kevin Doyoon, Lhoták, Šárka, Naeim, Magda, Platko, Khrystyna, Lebeau, Paul, Byun, Jae Hyun, Shayegan, Bobby, Krepinsky, Joan C., Rayner, Katey J., Marchiò, Serena, Pasqualini, Renata, Arap, Wadih, Austin, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338388/
https://ncbi.nlm.nih.gov/pubmed/30568038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99363
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