Calcium as a reliable marker for the quantitative assessment of endoplasmic reticulum stress in live cells

por Lebeau, Paul F., Platko, Khrystyna, Byun, Jae Hyun, Austin, Richard C.
Publicado en J Biol Chem (2021)

The trypan blue cellular debris assay: a novel low-cost method for the rapid quantification of cell death

por Lebeau, Paul F., Chen, Jack, Byun, Jae Hyun, Platko, Khrystyna, Austin, Richard C.
Publicado en MethodsX (2019)

Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice

por Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, MacDonald, Melissa E., Poon, Samantha V., Faiyaz, Mahi, Seidah, Nabil G., Austin, Richard C.
Publicado en J Biol Chem (2019)

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained

por Lebeau, Paul, Platko, Khrystyna, Al-Hashimi, Ali A., Byun, Jae Hyun, Lhoták, Šárka, Holzapfel, Nicholas, Gyulay, Gabriel, Igdoura, Suleiman A., Cool, David R., Trigatti, Bernardo, Seidah, Nabil G., Austin, Richard C.
Publicado en J Biol Chem (2018)

GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury

por Platko, Khrystyna, Lebeau, Paul F., Byun, Jae Hyun, Poon, Samantha V., Day, Emily A., MacDonald, Melissa E., Holzapfel, Nicholas, Mejia-Benitez, Aurora, Maclean, Kenneth N., Krepinsky, Joan C., Austin, Richard C.
Publicado en Mol Metab (2019)

Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice

por Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, Al-Hashimi, Ali A., Lhoták, Šárka, MacDonald, Melissa E., Mejia-Benitez, Aurora, Prat, Annik, Igdoura, Suleiman A., Trigatti, Bernardo, Maclean, Kenneth N., Seidah, Nabil G., Austin, Richard C.
Publicado en JHEP Rep (2019)

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions

por Crane, Elizabeth D., Al-Hashimi, Ali A., Chen, Jack, Lynn, Edward G., Won, Kevin Doyoon, Lhoták, Šárka, Naeim, Magda, Platko, Khrystyna, Lebeau, Paul, Byun, Jae Hyun, Shayegan, Bobby, Krepinsky, Joan C., Rayner, Katey J., Marchiò, Serena, Pasqualini, Renata, Arap, Wadih, Austin, Richard C.
Publicado en JCI Insight (2018)

The loss-of-function PCSK9(Q152H) variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

por Lebeau, Paul F., Wassef, Hanny, Byun, Jae Hyun, Platko, Khrystyna, Ason, Brandon, Jackson, Simon, Dobroff, Joshua, Shetterly, Susan, Richards, William G., Al-Hashimi, Ali A., Won, Kevin Doyoon, Mbikay, Majambu, Prat, Annik, Tang, An, Paré, Guillaume, Pasqualini, Renata, Seidah, Nabil G., Arap, Wadih, Chrétien, Michel, Austin, Richard C.
Publicado en J Clin Invest (2021)