The loss-of-function PCSK9(Q152H) variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

Individuals harboring the loss-of-function (LOF) proprotein convertase subtilisin/kexin type 9 Gln152His variation (PCSK9(Q152H)) have low circulating low-density lipoprotein cholesterol levels and are therefore protected against cardiovascular disease (CVD). This uncleavable form of proPCSK9, howev...

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Publicado en:J Clin Invest
Autores principales: Lebeau, Paul F., Wassef, Hanny, Byun, Jae Hyun, Platko, Khrystyna, Ason, Brandon, Jackson, Simon, Dobroff, Joshua, Shetterly, Susan, Richards, William G., Al-Hashimi, Ali A., Won, Kevin Doyoon, Mbikay, Majambu, Prat, Annik, Tang, An, Paré, Guillaume, Pasqualini, Renata, Seidah, Nabil G., Arap, Wadih, Chrétien, Michel, Austin, Richard C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810474/
https://ncbi.nlm.nih.gov/pubmed/33211673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128650
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