Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions

The 78-kDa glucose-regulated protein (GRP78) is an ER molecular chaperone that aids in protein folding and secretion. However, pathological conditions that cause ER stress can promote the relocalization of GRP78 to the cell surface (csGRP78), where it acts as a signaling receptor to promote cancer p...

詳細記述

保存先:
書誌詳細
出版年:JCI Insight
主要な著者: Crane, Elizabeth D., Al-Hashimi, Ali A., Chen, Jack, Lynn, Edward G., Won, Kevin Doyoon, Lhoták, Šárka, Naeim, Magda, Platko, Khrystyna, Lebeau, Paul, Byun, Jae Hyun, Shayegan, Bobby, Krepinsky, Joan C., Rayner, Katey J., Marchiò, Serena, Pasqualini, Renata, Arap, Wadih, Austin, Richard C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2018
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338388/
https://ncbi.nlm.nih.gov/pubmed/30568038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99363
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