Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates

Translation of drug candidates into clinical settings requires demonstration of preclinical efficacy and formal toxicology analysis for filling an Investigational New Drug (IND) application with the US Food & Drug Administration (FDA). Here, we investigate the membrane-associated glucose respons...

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Udgivet i:Pharmacogenomics J
Main Authors: Staquicini, Daniela I., D’Angelo, Sara, Ferrara, Fortunato, Karjalainen, Katja, Sharma, Geetanjali, Smith, Tracey L., Tarleton, Christy A., Jaalouk, Diana E., Kuniyasu, Akihiko, Baze, Wallace B., Chaffee, Beth K., Hanley, Patrick W., Barnhart, Kirstin F., Koivunen, Erkki, Marchiò, Serena, Sidman, Richard L., Cortes, Jorge E., Kantarjian, Hagop M., Arap, Wadih, Pasqualini, Renata
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824482/
https://ncbi.nlm.nih.gov/pubmed/29205207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2017.46
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