Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates

Translation of drug candidates into clinical settings requires demonstration of preclinical efficacy and formal toxicology analysis for filling an Investigational New Drug (IND) application with the US Food & Drug Administration (FDA). Here, we investigate the membrane-associated glucose respons...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pharmacogenomics J
Auteurs principaux: Staquicini, Daniela I., D’Angelo, Sara, Ferrara, Fortunato, Karjalainen, Katja, Sharma, Geetanjali, Smith, Tracey L., Tarleton, Christy A., Jaalouk, Diana E., Kuniyasu, Akihiko, Baze, Wallace B., Chaffee, Beth K., Hanley, Patrick W., Barnhart, Kirstin F., Koivunen, Erkki, Marchiò, Serena, Sidman, Richard L., Cortes, Jorge E., Kantarjian, Hagop M., Arap, Wadih, Pasqualini, Renata
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824482/
https://ncbi.nlm.nih.gov/pubmed/29205207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2017.46
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