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Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia
BACKGROUND: We introduce an ex vivo methodology to perform drug library screening against human leukemia. METHOD: Our strategy relies on human blood or bone marrow cultures under hypoxia; under these conditions, leukemia cells deplete oxygen faster than normal cells, causing a hemoglobin oxygenation...
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| Publicado no: | Cancer |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457455/ https://ncbi.nlm.nih.gov/pubmed/24496871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28419 |
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