Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia

BACKGROUND: We introduce an ex vivo methodology to perform drug library screening against human leukemia. METHOD: Our strategy relies on human blood or bone marrow cultures under hypoxia; under these conditions, leukemia cells deplete oxygen faster than normal cells, causing a hemoglobin oxygenation...

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Bibliografiske detaljer
Udgivet i:Cancer
Main Authors: Karjalainen, Katja, Pasqualini, Renata, Cortes, Jorge E., Kornblau, Steven M., Lichtiger, Benjamin, O'Brien, Susan, Kantarjian, Hagop M., Sidman, Richard L., Arap, Wadih, Koivunen, Erkki
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457455/
https://ncbi.nlm.nih.gov/pubmed/24496871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28419
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