Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol()

OBJECTIVE: Low-density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are opposing regulators of plasma LDL-cholesterol levels. The PCSK9 gene exhibits many single or compound polymorphisms within or among mammalian species. This is case between the SPRET/EiJ (...

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Bibliographic Details
Published in:Mol Genet Metab Rep
Main Authors: Sirois, Francine, Chrétien, Michel, Mbikay, Majambu
Format: Artigo
Language:Inglês
Published: Elsevier 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155046/
https://ncbi.nlm.nih.gov/pubmed/27995077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2016.11.006
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