Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice

The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly. Although this condition is generally benign, accumulating evidence now suggests that patients with NAFLD are also at increased risk of cardiovascular disease (CVD); the leading cause of death in developed na...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, MacDonald, Melissa E., Poon, Samantha V., Faiyaz, Mahi, Seidah, Nabil G., Austin, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556582/
https://ncbi.nlm.nih.gov/pubmed/31004037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008094
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