Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice

The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly. Although this condition is generally benign, accumulating evidence now suggests that patients with NAFLD are also at increased risk of cardiovascular disease (CVD); the leading cause of death in developed na...

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Udgivet i:J Biol Chem
Main Authors: Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, MacDonald, Melissa E., Poon, Samantha V., Faiyaz, Mahi, Seidah, Nabil G., Austin, Richard C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556582/
https://ncbi.nlm.nih.gov/pubmed/31004037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008094
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