The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Palacios, Antonela R., Mojica, María F., Giannini, Estefanía, Taracila, Magdalena A., Bethel, Christopher R., Alzari, Pedro M., Otero, Lisandro H., Klinke, Sebastián, Llarrull, Leticia I., Bonomo, Robert A., Vila, Alejandro J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325180/
https://ncbi.nlm.nih.gov/pubmed/30348667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01754-18
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