The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Palacios, Antonela R., Mojica, María F., Giannini, Estefanía, Taracila, Magdalena A., Bethel, Christopher R., Alzari, Pedro M., Otero, Lisandro H., Klinke, Sebastián, Llarrull, Leticia I., Bonomo, Robert A., Vila, Alejandro J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325180/
https://ncbi.nlm.nih.gov/pubmed/30348667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01754-18
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