The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Palacios, Antonela R., Mojica, María F., Giannini, Estefanía, Taracila, Magdalena A., Bethel, Christopher R., Alzari, Pedro M., Otero, Lisandro H., Klinke, Sebastián, Llarrull, Leticia I., Bonomo, Robert A., Vila, Alejandro J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325180/
https://ncbi.nlm.nih.gov/pubmed/30348667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01754-18
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