The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Palacios, Antonela R., Mojica, María F., Giannini, Estefanía, Taracila, Magdalena A., Bethel, Christopher R., Alzari, Pedro M., Otero, Lisandro H., Klinke, Sebastián, Llarrull, Leticia I., Bonomo, Robert A., Vila, Alejandro J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325180/
https://ncbi.nlm.nih.gov/pubmed/30348667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01754-18
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