The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Palacios, Antonela R., Mojica, María F., Giannini, Estefanía, Taracila, Magdalena A., Bethel, Christopher R., Alzari, Pedro M., Otero, Lisandro H., Klinke, Sebastián, Llarrull, Leticia I., Bonomo, Robert A., Vila, Alejandro J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325180/
https://ncbi.nlm.nih.gov/pubmed/30348667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01754-18
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