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Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution

The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able to hydrolyze not only penicillins, but also th...

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Detalhes bibliográficos
Main Authors: Meini, María-Rocío, Llarrull, Leticia I., Vila, Alejandro J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212336/
https://ncbi.nlm.nih.gov/pubmed/25364574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics3030285
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