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Mimicking natural evolution in metallo-β-lactamases through second-shell ligand mutations
Metallo-β-lactamases (MBLs) represent the latest generation of β-lactamases. The structural diversity and broad substrate profile of MBLs allow them to confer resistance to most β-lactam antibiotics. To explore the evolutionary potential of these enzymes, we have subjected the Bacillus cereus MBL (B...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1236536/ https://ncbi.nlm.nih.gov/pubmed/16172409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503495102 |
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