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Metallo-β-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions
A number of multiresistant bacterial pathogens inactivate antibiotics by producing Zn(II)-dependent β-lactamases. We show that metal uptake leading to an active dinuclear enzyme in the periplasmic space of Gram-negative bacteria is ensured by a cysteine residue, an unusual metal ligand in oxidizing...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3470787/ https://ncbi.nlm.nih.gov/pubmed/22729148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1005 |
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