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Catalytic Role of the Metal Ion in the Metallo-β-lactamase GOB
Metallo-β-lactamases (MβLs) stand as one of the main mechanisms of bacterial resistance toward carbapenems. The rational design of an inhibitor for MβLs has been limited by an incomplete knowledge of their catalytic mechanism and by the structural diversity of their active sites. Here we show that t...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836117/ https://ncbi.nlm.nih.gov/pubmed/20007696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.063743 |
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