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Probing the role of Met221 in the unusual metallo-β-lactamase GOB-18

Metallo-β-lactamases (MβLs) are the main mechanism of bacterial resistance against last generation β-lactam antibiotics such as carbapenems. Most MβLs display unusual structural features in their active sites, such as binuclear zinc centers without carboxylate bridging ligands, and/or a Cys ligand i...

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Main Authors: Lisa, María-Natalia, Morán-Barrio, Jorgelina, Guindón, María-Fernanda, Vila, Alejandro J.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593996/
https://ncbi.nlm.nih.gov/pubmed/23113650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic301801h
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