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Probing the role of Met221 in the unusual metallo-β-lactamase GOB-18
Metallo-β-lactamases (MβLs) are the main mechanism of bacterial resistance against last generation β-lactam antibiotics such as carbapenems. Most MβLs display unusual structural features in their active sites, such as binuclear zinc centers without carboxylate bridging ligands, and/or a Cys ligand i...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593996/ https://ncbi.nlm.nih.gov/pubmed/23113650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic301801h |
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