Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs effective against all enzymes. Bisthiazolidines...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Hinchliffe, Philip, González, Mariano M., Mojica, Maria F., González, Javier M., Castillo, Valerie, Saiz, Cecilia, Kosmopoulou, Magda, Tooke, Catherine L., Llarrull, Leticia I., Mahler, Graciela, Bonomo, Robert A., Vila, Alejandro J., Spencer, James
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932952/
https://ncbi.nlm.nih.gov/pubmed/27303030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601368113
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