Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs effective against all enzymes. Bisthiazolidines...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Hinchliffe, Philip, González, Mariano M., Mojica, Maria F., González, Javier M., Castillo, Valerie, Saiz, Cecilia, Kosmopoulou, Magda, Tooke, Catherine L., Llarrull, Leticia I., Mahler, Graciela, Bonomo, Robert A., Vila, Alejandro J., Spencer, James
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932952/
https://ncbi.nlm.nih.gov/pubmed/27303030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601368113
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