Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs effective against all enzymes. Bisthiazolidines...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hinchliffe, Philip, González, Mariano M., Mojica, Maria F., González, Javier M., Castillo, Valerie, Saiz, Cecilia, Kosmopoulou, Magda, Tooke, Catherine L., Llarrull, Leticia I., Mahler, Graciela, Bonomo, Robert A., Vila, Alejandro J., Spencer, James
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932952/
https://ncbi.nlm.nih.gov/pubmed/27303030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601368113
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