Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major public health threat. Zn(II)-dependent or metallo-β-lactamases (MBLs) produced by these bacteria inactivate most β-lactam antibiotics, including the carbapenems, which are “last line therapies” for life-threat...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Infect Dis
Egile Nagusiak: González, Mariano M., Kosmopoulou, Magda, Mojica, Maria F., Castillo, Valerie, Hinchliffe, Philip, Pettinati, Ilaria, Brem, Jürgen, Schofield, Christopher J., Mahler, Graciela, Bonomo, Robert A., Llarrull, Leticia I., Spencer, James, Vila, Alejandro J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064445/
https://ncbi.nlm.nih.gov/pubmed/27623409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00046
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