Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis

Nonalcoholic fatty liver disease (NAFLD) is characterized by abnormal accumulation of triglycerides (TG) in the liver and other metabolic syndrome symptoms, but its molecular genetic causes are not completely understood. Here, we show that mice deficient for ubiquitin ligase (E3) Smad ubiquitin regu...

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Pubblicato in:PLoS Biol
Autori principali: Zhu, Kun, Tang, Yi, Xu, Xuan, Dang, Hien, Tang, Liu-Ya, Wang, Xiang, Wang, Xin Wei, Zhang, Ying E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317813/
https://ncbi.nlm.nih.gov/pubmed/30566427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000091
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