Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis

Nonalcoholic fatty liver disease (NAFLD) is characterized by abnormal accumulation of triglycerides (TG) in the liver and other metabolic syndrome symptoms, but its molecular genetic causes are not completely understood. Here, we show that mice deficient for ubiquitin ligase (E3) Smad ubiquitin regu...

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Publicado en:PLoS Biol
Autores principales: Zhu, Kun, Tang, Yi, Xu, Xuan, Dang, Hien, Tang, Liu-Ya, Wang, Xiang, Wang, Xin Wei, Zhang, Ying E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317813/
https://ncbi.nlm.nih.gov/pubmed/30566427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000091
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