Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis

Nonalcoholic fatty liver disease (NAFLD) is characterized by abnormal accumulation of triglycerides (TG) in the liver and other metabolic syndrome symptoms, but its molecular genetic causes are not completely understood. Here, we show that mice deficient for ubiquitin ligase (E3) Smad ubiquitin regu...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Zhu, Kun, Tang, Yi, Xu, Xuan, Dang, Hien, Tang, Liu-Ya, Wang, Xiang, Wang, Xin Wei, Zhang, Ying E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317813/
https://ncbi.nlm.nih.gov/pubmed/30566427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000091
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