PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia

BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA level...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Gilbert, Tonya M., Zürcher, Nicole R., Wu, Christine J., Bhanot, Anisha, Hightower, Baileigh G., Kim, Minhae, Albrecht, Daniel S., Wey, Hsiao-Ying, Schroeder, Frederick A., Rodriguez-Thompson, Anais, Morin, Thomas M., Hart, Kamber L., Pellegrini, Amelia M., Riley, Misha M., Wang, Changning, Stufflebeam, Steven M., Haggarty, Stephen J., Holt, Daphne J., Loggia, Marco L., Perlis, Roy H., Brown, Hannah E., Roffman, Joshua L., Hooker, Jacob M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307962/
https://ncbi.nlm.nih.gov/pubmed/30530989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123743
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