PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia

BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA level...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Gilbert, Tonya M., Zürcher, Nicole R., Wu, Christine J., Bhanot, Anisha, Hightower, Baileigh G., Kim, Minhae, Albrecht, Daniel S., Wey, Hsiao-Ying, Schroeder, Frederick A., Rodriguez-Thompson, Anais, Morin, Thomas M., Hart, Kamber L., Pellegrini, Amelia M., Riley, Misha M., Wang, Changning, Stufflebeam, Steven M., Haggarty, Stephen J., Holt, Daphne J., Loggia, Marco L., Perlis, Roy H., Brown, Hannah E., Roffman, Joshua L., Hooker, Jacob M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307962/
https://ncbi.nlm.nih.gov/pubmed/30530989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123743
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