PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia

BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA level...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gilbert, Tonya M., Zürcher, Nicole R., Wu, Christine J., Bhanot, Anisha, Hightower, Baileigh G., Kim, Minhae, Albrecht, Daniel S., Wey, Hsiao-Ying, Schroeder, Frederick A., Rodriguez-Thompson, Anais, Morin, Thomas M., Hart, Kamber L., Pellegrini, Amelia M., Riley, Misha M., Wang, Changning, Stufflebeam, Steven M., Haggarty, Stephen J., Holt, Daphne J., Loggia, Marco L., Perlis, Roy H., Brown, Hannah E., Roffman, Joshua L., Hooker, Jacob M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307962/
https://ncbi.nlm.nih.gov/pubmed/30530989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123743
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