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Insights into neuroepigenetics through human histone deacetylase PET imaging

Epigenetic dysfunction is implicated in many neurological and psychiatric diseases, including Alzheimer’s disease and schizophrenia. Consequently, histone deacetylases (HDACs) are being aggressively pursued as therapeutic targets. However, a fundamental knowledge gap exists regarding the expression...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Wey, H-Y, Gilbert, T.M., Zürcher, N.R., She, A., Bhanot, A., Taillon, B.D., Schroeder, F.A., Wang, C., Haggarty, S. J., Hooker, J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784409/
https://ncbi.nlm.nih.gov/pubmed/27510902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf7551
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