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Fenestrations control resting-state block of a voltage-gated sodium channel
Potency of drug action is usually determined by binding to a specific receptor site on target proteins. In contrast to this conventional paradigm, we show here that potency of local anesthetics (LAs) and antiarrhythmic drugs (AADs) that block sodium channels is controlled by fenestrations that allow...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6304959/ https://ncbi.nlm.nih.gov/pubmed/30518562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814928115 |
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