Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

BACKGROUND: Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We pr...

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Detaylı Bibliyografya
Yayımlandı:J Exp Clin Cancer Res
Asıl Yazarlar: Pisanu, Maria Elena, Maugeri-Saccà, Marcello, Fattore, Luigi, Bruschini, Sara, De Vitis, Claudia, Tabbì, Eugenio, Bellei, Barbara, Migliano, Emilia, Kovacs, Daniela, Camera, Emanuela, Picardo, Mauro, Jakopin, Ziga, Cippitelli, Claudia, Bartolazzi, Armando, Raffa, Salvatore, Torrisi, Maria Rosaria, Fulciniti, Franco, Ascierto, Paolo A., Ciliberto, Gennaro, Mancini, Rita
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2018
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298024/
https://ncbi.nlm.nih.gov/pubmed/30558661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0989-7
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