Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma

Patients with metastatic melanoma bearing V600 mutations in BRAF oncogene clinically benefit from the treatment with BRAF inhibitors alone or in combination with MEK inhibitors. However, a limitation to such treatment is the occurrence of resistance. Tackling the adaptive changes helping cells survi...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Fattore, Luigi, Malpicci, Debora, Marra, Emanuele, Belleudi, Francesca, Noto, Alessia, De Vitis, Claudia, Pisanu, Maria Elena, Coluccia, Pierpaolo, Camerlingo, Rosa, Roscilli, Giuseppe, Ribas, Antoni, Di Napoli, Arianna, Torrisi, Maria Rosaria, Aurisicchio, Luigi, Ascierto, Paolo Antonio, Mancini, Rita, Ciliberto, Gennaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694796/
https://ncbi.nlm.nih.gov/pubmed/26208478
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