Activation of an early feedback survival loop involving phospho-ErbB3 is a general response of melanoma cells to RAF/MEK inhibition and is abrogated by anti-ErbB3 antibodies

BACKGROUND: Treatment of advanced melanoma has been improved with the advent of the BRAF inhibitors. However, a limitation to such treatment is the occurrence of resistance. Several mechanisms have been identified to be responsible for the development of resistance, either MEK-dependent or MEK-indep...

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Bibliographische Detailangaben
Hauptverfasser: Fattore, Luigi, Marra, Emanuele, Pisanu, Maria Elena, Noto, Alessia, de Vitis, Claudia, Belleudi, Francesca, Aurisicchio, Luigi, Mancini, Rita, Torrisi, Maria Rosaria, Ascierto, Paolo Antonio, Ciliberto, Gennaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729364/
https://ncbi.nlm.nih.gov/pubmed/23890105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-180
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