Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

BACKGROUND: Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We pr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Pisanu, Maria Elena, Maugeri-Saccà, Marcello, Fattore, Luigi, Bruschini, Sara, De Vitis, Claudia, Tabbì, Eugenio, Bellei, Barbara, Migliano, Emilia, Kovacs, Daniela, Camera, Emanuela, Picardo, Mauro, Jakopin, Ziga, Cippitelli, Claudia, Bartolazzi, Armando, Raffa, Salvatore, Torrisi, Maria Rosaria, Fulciniti, Franco, Ascierto, Paolo A., Ciliberto, Gennaro, Mancini, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298024/
https://ncbi.nlm.nih.gov/pubmed/30558661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0989-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados