Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

BACKGROUND: Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We pr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Pisanu, Maria Elena, Maugeri-Saccà, Marcello, Fattore, Luigi, Bruschini, Sara, De Vitis, Claudia, Tabbì, Eugenio, Bellei, Barbara, Migliano, Emilia, Kovacs, Daniela, Camera, Emanuela, Picardo, Mauro, Jakopin, Ziga, Cippitelli, Claudia, Bartolazzi, Armando, Raffa, Salvatore, Torrisi, Maria Rosaria, Fulciniti, Franco, Ascierto, Paolo A., Ciliberto, Gennaro, Mancini, Rita
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298024/
https://ncbi.nlm.nih.gov/pubmed/30558661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0989-7
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