Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively active innate immune block to lentiviral transduction that can be efficiently overcome...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Petrillo, Carolina, Thorne, Lucy G., Unali, Giulia, Schiroli, Giulia, Giordano, Anna M.S., Piras, Francesco, Cuccovillo, Ivan, Petit, Sarah J., Ahsan, Fatima, Noursadeghi, Mahdad, Clare, Simon, Genovese, Pietro, Gentner, Bernhard, Naldini, Luigi, Towers, Greg J., Kajaste-Rudnitski, Anna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292841/
https://ncbi.nlm.nih.gov/pubmed/30416070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.10.008
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller